Is there really an advantage to using the related cord blood Independent cord blood transplantation?
Not surprisingly, yes! Recently, the results of patients who were transplanted for the treatment of hereditary syndromes of bone marrow failure is related (brother) or allogeneic cord blood from unrelated, were published (2011 Haematologica 96 (1): 134-141 ). This study reported 64 patients, 20 who were treated with cord blood is associated and 44 who were treated with unrelated cord blood - and related transplants showed much more successful
hematopoietic (blood) stem cell transplantation is the only cure! for most patients with these syndromes, which include, among others, the Diamond-Blackfan anemia, severe congenital neutropenia and Shwachman-Diamond syndrome. Patients treated with cord blood bound, obtained from a brother, had greater neutrophils (95%) and platelets (90%) of recoveries, compared to those treated with independent cord blood (57 % and 52%, respectively). The incidence of chronic graft against the host was lower among patients who received combined cord blood (11%) compared to those treated unrelated cord blood (53%).
More importantly, overall survival 2 years in patients treated with cord blood from related was 95%, compared to the survival of 61% of patients treated with cord blood unrelated.
The authors concluded that for patients with hereditary bone to bone deficiency syndromes, transplant cord blood related is associated with excellent results!